The history of the church of Christ of Florence began in July 1953 with the presence of Carl and Frankie Mitchell and Lido and Tina Petrini. Emilio Fancelli was the first to be baptized in September of the same year.

The church of Christ of Florence slowly came together, the group met Sunday afternoons to get better acquainted and to discuss their beliefs. After several months, some free studies to learn English, combined with Bible studies, were developed, and some 70 students were enrolled. After four months, seven students accepted Christ by baptism.

As time went by, the situation became more complicated: Carl Mitchell was charged by the police and was not allowed to teach English without the permission of the Department of Public Education. In spite of his formal request, in the answer which arrived two years later, he was confirmed denial of the use of English study for propaganda for the church of Christ. In the meantime however, the brethren had not lost hope and at the end of three laborious years, they had brought the number of baptized believers to 55.

The disaster of the flood (November 1966) did not spare the meeting place, at the time in Via dei Saponai, just a few meters from the Arno river. Thanks to the solidarity of many brethren, the church of Christ of Florence was able to purchase the Ex-Cappella Demidoff in Via San Donato, the present church building.

The Bible School of Florence, a christian theology school, was founded in 1958. It is presently located in Scandicci (Le Bagnese) as a center for studies on evangelism.